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RubrikUnfallverhütung zurück
ThemaSchweinegrippe Impferfahrungen81 Beiträge
AutorMark8us 8W., Schwäbisch Gmünd / Baden - Württemberg592711
Datum17.11.2009 21:42      MSG-Nr: [ 592711 ]16091 x gelesen
Themengruppe:
  • Schweinegrippe [H1N1]

    • Hallo Gemeinde,

    zur Info, kam eben per promedMAIL hier an:


    Geschrieben von promedMAIL
    INFLUENZA PANDEMIC (H1N1) 2009 (105): RHINOVIRUS INTERFERENCE
    *************************************************************
    A ProMED-mail post
    <http://www.promedmail.org>
    ProMED-mail is a program of the
    International Society for Infectious Diseases
    <http://www.isid.org>

    Date: Thu 12 Nov 2009
    Source: The New Scientist, issue 2734 [edited]
    <http://www.newscientist.com/article/mg20427345.100-common-cold-may-hold-off-swine-flu.html>


    Common cold may hold off swine flu
    ----------------------------------
    A virus that causes the common cold may be saving people from swine
    flu [pandemic (H1N1) 2009 influenza virus infection]. If this
    intriguing idea turns out to be true, it would explain why swine
    flu's autumn wave has been slow to take off in some countries and
    point to new ways to fight flu.

    "It is really surprising that there has not been more pandemic flu
    activity in many European countries," says Arnold Monto, an
    epidemiologist at the University of Michigan, Ann Arbor. In France,
    flu cases rose in early September [2009], then stayed at about 160
    per 100 000 people until late October, when numbers started rising again.

    The delayed rise was puzzling, says Jean-Sebastien Casalegno of the
    French national flu lab at the University of Lyon. He reports that
    the percentage of throat swabs from French respiratory illnesses that
    tested positive for swine flu fell in September, while at the same
    time rhinovirus, which causes colds, rose. He told New Scientist that
    in late October, rhinovirus fell -- at the same time as flu rose. He
    suspects rhinovirus may have blocked the spread of swine flu via a
    process called viral interference. This is thought to occur when one
    virus blocks another.

    "We think that when you get one infection, it turns on your antiviral
    defences, and excludes the other viruses," says Ab Osterhaus at the
    University of Rotterdam in the Netherlands.

    How important such interference is in viral epidemics is unclear.
    However, there are also cases in which there is no interference, and
    people catch 2 viruses at the same time. Normally, we don't get a
    chance to see how rhinovirus affects flu, because flu epidemics
    usually strike in winter; whereas rhinovirus hits when schools start
    (late summer in the northern hemisphere). But this year the pandemic
    meant flu arrived early -- and France isn't the only country in which
    rhinovirus seems to have held it at bay.

    In Eurosurveillance last month [see reference below}, Mia Brytting of
    the Swedish Institute for Infectious Disease Control in Solna
    reported a rise in rhinovirus coupled with a swine flu lull just
    after school resumed in Sweden at the end of August [2009]. She too
    says rhinovirus has now fallen, as flu has climbed. Researchers in
    Norway report rhinovirus rose there as flu fell in August, while Ian
    Mackay at the University of Queensland found the same trend in
    Australia. What's more, in March, Mackay reported that people with
    rhinovirus are less likely to be infected with a 2nd virus than
    people with other viruses, and are just one-third as likely to have
    simultaneous seasonal flu (Journal of Clinical Virology, DOI:
    10.1016/j.jcv.2009.03.008).

    So why hasn't the US, for example, seen a dip in pandemic cases
    during a back-to-school rhinovirus outbreak? Mackay speculates that
    interference from rhinovirus may not be enough to fend off flu if
    someone is exposed repeatedly. There were far more cases of swine flu
    in the US in September than in Europe. The effects of rhinovirus,
    often dismissed as "only" a cold, are too poorly understood, say all
    the researchers. Its seeming ability to block swine flu may already
    have saved lives in France by buying the nation time before the
    vaccine arrived. It may even lead to a drug that induces the
    antiviral state, but without the sniffles.

    [Byline: Debora MacKenzie]

    --
    Communicated by:
    ProMED-mail Rapporteur Brent Barrett

    [The reference for the Eurosurveillance publication cited above is
    the following: Eurosurveillance, Volume 14, Issue 40, 08 October 2009
    <http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19354>.
    This paper by A Linde et al. is titled: Does viral interference
    affect the spread of influenza. The summary reads: "This short
    communication hypothesis that rhinovirus epidemics occurring after
    start of school may interfere with the spread of influenza during the
    period when warm and humid climate decreases the influenza spread by
    aerosol. Limited laboratory data supporting this hypothesis are
    included in the article, but the report is written mainly to
    stimulate interest and research concerning the possibility that viral
    interaction may affect influenza epidemiology."

    There are many viral respiratory pathogens and it is not unreasonable
    to hypothesize that some or all of these might interfere with the
    replication of influenza virus, which is itself susceptible to
    auto-interference by the generation defective interfering particles
    during replication (Indeed such defective interfering particles may
    in time be harnessed as specific therapeutic agents). The
    identification of rhinoviruses as interfering agents is partly a
    consequence of the surveillance activities associated with this
    virus. Interference by other viral respiratory pathogens will remain
    unrecognised in the absence of systematic surveillance. - Mod.CP]

    Gruß, MaWe

    Um schon vorab die größte Sorge vieler Ausländer vorwegzunehmen: Die Deutschen sind im Allgemeinen sehr, sehr nett, sie haben schon seit 60 Jahren kein Nachbarland mehr überfallen und man kann mit ihnen sogar lachen! (De Volkskrant, Niederlande)

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